The player controls the eponymous Isaac, a young boy whose mother, convinced that she is doing God's work, strips him of everything and locks him in his room. Similar to the original Binding of Isaac, the plot is based on the biblical story of the same name and was inspired by McMillen's religious upbringing. A third expansion, Repentance, was announced in September 2018. Two expansions have been released, Afterbirth and Afterbirth+, in October 2015 and January 2017, respectively, with more game content and gameplay modes Afterbirth+ also added support for user-created content. This platform had limitations and led McMillen to work with Nicalis to produce Rebirth with a more-advanced game engine, which in turn enabled the substantial addition of new content and gameplay features. Rebirth is a remake of The Binding of Isaac, which was developed by McMillen and Florian Himsl and released in 2011 as an Adobe Flash application. A version for the Nintendo Switch was released on March 17, 2017. After an initial rejection due to its controversial content, Nicalis released Rebirth on iOS on January 11, 2017. Rebirth was released for Microsoft Windows, OS X, Linux, PlayStation 4, and PlayStation Vita in November 2014, and for Xbox One, New Nintendo 3DS, and Wii U in July 2015. Invincibility and shields will not trigger a sacrifice (including Holy Mantle).The Binding of Isaac: Rebirth is an indie roguelike video game designed by Edmund McMillen and developed and published by Nicalis.Dying in a sacrifice room while holding Missing Poster will unlock The Lost.The Dark Room teleport still happens on any floor even if you haven't unlocked it yet.
Historically, Sacrifice Rooms have always been pretty darn useless in The Binding of Isaac, but lucky owners of the Afterbirth DLC will find they've had a huge revamp, significantly increasing the quality of rewards you can find.